Taking place two years after the events of Last Exile, Last Exile: Fam, The Silver Wing is set on Earth, the original home world of the colonists of Prester. The new story focuses on Fam Fan Fan and Giselle Collette, two vespa pilots who work as Sky Pirates where they capture and sell battleships for a living. Fam and Giselle get into an adventure when they and the Sky Pirates rescue the Princesses of the Turan Kingdom, Liliana il Grazioso Merlo Turan and her younger sister, Millia Il Velch Cutrettola Turan, from the clutches of mighty Ades Federation. Led by Empress Sārā Augusta and Premier Luscinia Hāfez, the Ades Federation is on an all out war against the nations who are descendants of immigrants who came back to Earth by Exile ships. As Ades was the only nation to stay on Earth when the planet was in state of chaos and ruined, Luscinia believes the immigrants of Exile have no right to return to Earth since their ancestors abandoned Earth when it was in chaos only to return when Earth was viable to live on again and force the original inhabitants of Earth off their lands to form their own nations. To return these lands to their original inhabitants, Luscinia leads the Ades Federation to conquer the immigrant nations and destroy their armies with Turan being one of them.
After Luscinia kidnaps Liliana, who has the ability to control an Exile, Luscinia summons an Exile to destroy the capital of Turan, killing its soldiers and the King of Turan, leading to Turan surrendering to Ades. With everything she cared for lost, Millia is given refuge by the Sky Pirates where Fam promises to help Millia regain her kingdom.